Glyburide Regulates UCP1 Expression in Adipocytes Independent of K_ATP Channel Blockade.

ABSTRACT: Identification of safe and effective compounds to increase or activate UCP1 expression in brown or white adipocytes remains a potent therapeutic strategy to combat obesity. Here we reported that, glyburide, one of the FDA-approved drugs currently used to treat type 2 diabetes, can significantly enhance UCP1 expression in both brown and white adipocytes. Glyburide-fed mice exhibited a clear resistance to high-fat diet-induced obesity, reduced blood triglyceride level, and increased UCP1 expression in brown adipose tissue. Moreover, in situ injection of glyburide to inguinal white adipose tissue remarkably enhanced UCP1 expression and increased thermogenesis. Further mechanistic studies indicated that the glyburide effect in UCP1 expression in adipocytes was K_ATP channel in

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC7452185 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature