Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success.

ABSTRACT: Preclinical large animal models of heart failure (HF) play a critical and expanding role in translating basic science findings to the development and clinical approval of novel therapeutics and devices. The complex combination of cardiovascular events and risk factors leading to HF has proved challenging for the development of new treatments for these patients. This state-of-the-art review presents historical and recent studies in porcine, ovine, and canine models of HF and outlines existing methodologies and physiological phenotypes. The translational importance of large animal studies to clinical success is also highlighted with an overview of recent devices approved by the Food and Drug Administration, together with preclinical HF animal studies used to aid both development and safety a

SUBMITTER: Silva KAS 

PROVIDER: S-EPMC7452204 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature