Psoriatic skin inflammation induces a pre-diabetic phenotype via the endocrine actions of skin secretome.

ABSTRACT:

Objective

Psoriasis is a chronic inflammatory skin disease that is thought to affect ∼2% of the global population. Psoriasis has been associated with ∼30% increased risk of developing type 2 diabetes (T2D), with numerous studies reporting that psoriasis is an independent risk-factor for T2D, separate from underlying obesity. Separately, studies of skin-specific transgenic mice have reported altered whole-body glucose homeostasis in these models. These studies imply a direct role for skin inflammation and dysfunction in mediating the onset of T2D in psoriasis patients, potentially via the endocrine effects of the skin secretome on key metabolic tissues. We used a combination of in vivo and ex vivo mouse models and ex vivo human imiquimod (IMQ) models to investigate the effects of ps

SUBMITTER: Evans EA 

PROVIDER: S-EPMC7452265 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature