Elevated levels of autoantibodies against DNAJC2 in sera of patients with atherosclerotic diseases.

ABSTRACT:

Background

Serum antibody markers have been increasingly identified not only for cancer and autoimmune diseases but also for atherosclerosis-related diseases such as acute ischemic stroke (AIS), acute myocardial infarction (AMI), diabetes mellitus (DM), and chronic kidney disease (CKD). Biomarkers for transient ischemic attack (TIA) and non-ST segment elevation acute coronary syndrome (NSTEACS) are potentially useful for detection of early phase of atherosclerotic changes against AIS and AMI, respectively.

Methods

We utilized serological identification of antigens by recombinant cDNA expression cloning (SEREX) using a human aortic endothelial cell cDNA phage library and sera from patients with TIA or NSTEACS. Serum antibody levels were measured by amplified luminescent proxi

SUBMITTER: Yoshida Y 

PROVIDER: S-EPMC7452465 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature