Effects of tumour necrosis factor on cardiovascular disease and cancer: A two-sample Mendelian randomization study.

ABSTRACT:

Background

Tumour necrosis factor (TNF) inhibitors are used in the treatment of certain autoimmune diseases but given the role of TNF in tumour biology and atherosclerosis, such therapies may influence the risk of cancer and cardiovascular disease. We conducted a Mendelian randomization study to explore whether TNF levels are causally related to cardiovascular disease and cancer.

Methods

Single-nucleotide polymorphisms associated with TNF levels at genome-wide significance were identified from a genome-wide association study of 30 912 European-ancestry individuals. Three TNF-associated single-nucleotide polymorphisms associated with higher risk of autoimmune diseases were used as instrumental variables. Summary-level data for 14 cardiovascular diseases, overall cancer and 14

SUBMITTER: Yuan S 

PROVIDER: S-EPMC7452586 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature