Interferon-α alters host glycosylation machinery during treated HIV infection.

ABSTRACT:

Background

A comprehensive understanding of host factors modulated by the antiviral cytokine interferon-α (IFNα) is imperative for harnessing its beneficial effects while avoiding its detrimental side-effects during HIV infection. Cytokines modulate host glycosylation which plays a critical role in mediating immunological functions. However, the impact of IFNα on host glycosylation has never been characterized.

Methods

We assessed the impact of pegylated IFNα2a on IgG glycome, as well as CD8⁺ T and NK cell-surface glycomes, of 18 HIV-infected individuals on suppressive antiretroviral therapy. We linked these glycomic signatures to changes in inflammation, CD8⁺ T and NK cell phenotypes, and HIV DNA.

Findings

We identified significant interactions

SUBMITTER: Giron LB 

PROVIDER: S-EPMC7452630 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature