The neuropeptide calcitonin gene-related peptide alpha is essential for bone healing.

ABSTRACT:

Background

Impaired fracture healing represents an ongoing clinical challenge, as treatment options remain limited. Calcitonin gene-related peptide (CGRP), a neuropeptide targeted by emerging anti-migraine drugs, is also expressed in sensory nerve fibres innervating bone tissue.

Method

Bone healing following a femoral osteotomy stabilized with an external fixator was analysed over 21 days in αCGRP-deficient and WT mice. Bone regeneration was evaluated by serum analysis, µCT analysis, histomorphometry and genome-wide expression analysis. Bone-marrow-derived osteoblasts and osteoclasts, as well as the CGRP antagonist olcegepant were employed for mechanistic studies.

Findings

WT mice with a femoral fracture display increased CGRP serum levels. αCGRP mRNA expression after

SUBMITTER: Appelt J 

PROVIDER: S-EPMC7452713 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature