Cognitive impairment three months after surgery is an independent predictor of survival time in glioblastoma patients.

ABSTRACT:

Purpose

Cognitive functioning is increasingly investigated for its prognostic value in glioblastoma (GBM) patients, but the association of cognitive status during early adjuvant treatment with survival time is unclear. The aim of this study was to determine whether cognitive performance three months after surgical resection predicted survival time, while using a clinically intuitive time ratio (TR) statistic.

Methods

Newly diagnosed patients with GBM undergoing resection between November 2010 and February 2018 completed computerized cognitive assessment 3 months after surgery with the CNS Vital Signs battery (8 measures). The association of cognitive performance (continuous Z scores and dichotomous impairment status; impaired vs. unimpaired) with survival time was assessed w

SUBMITTER: Butterbrod E 

PROVIDER: S-EPMC7452884 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature