Endometriosis Patients Show an Increased M2 Response in the Peritoneal CD14^+low/CD68^+low Macrophage Subpopulation Coupled with an Increase in the T-helper 2 and T-regulatory Cells.

ABSTRACT: Endometriosis is a chronic inflammatory disease associated with an impaired immune response at the site of lesion implantation. The ability of macrophages to respond to changes in their environment is critical for an effective immune response. However, the existing knowledge of the peritoneal immune cell populations, their activation state and contribution to the immunological changes that occur in endometriosis are still controversial and inconclusive. In this study, we have examined the relative abundance of peritoneal macrophage subtypes, in women with (n = 21) versus without (n = 18) endometriosis and disease-associated changes in the adaptive T cell response. Using flow cytometry, we showed that peritoneal fluid monocyte/macrophages are composed of two populations of cells that exhibi

SUBMITTER: Hudson QJ 

PROVIDER: S-EPMC7452931 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature