Atg7 Knockdown Reduces Chemerin Secretion in Murine Adipocytes.

ABSTRACT:

Context

In individuals with obesity, adipocyte endocrine function is affected by altered autophagy. Genetic variants in autophagy-related gene 7 (ATG7) correlated with serum chemerin (RARRES2) concentrations.

Objectives

To investigate a functional interplay between chemerin and ATG7, how it may relate to autophagy-mediated adipocyte dysfunction in obesity, and the relevance of genetic ATG7 variants in chemerin physiology.

Design

Adipose ATG7 mRNA expression and adiposity measures were available in two human study cohorts. The effect of a high-calorie diet on adipose Rarres2 and Atg7 expression was investigated in mice. In 3T3-L1 adipocytes, the effect of Atg7 knockdown on chemerin expression and secretion was studied. The influence of single nucleotide polymorphisms o

SUBMITTER: Heinitz S 

PROVIDER: S-EPMC7453040 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature