Diffusing capacity in normal-for-age spirometry and spirometric impairments, using reference equations from the global lung function initiative.

ABSTRACT:

Background

Reference equations from the Global Lung Function Initiative (GLI) are now available for both spirometry and diffusion. However, respiratory phenotypes defined by GLI-based measures of diffusion have not yet been evaluated in GLI-based normal-for-age spirometry or spirometric impairments.

Methods

We evaluated cross-sectional data from 2100 Caucasians, aged 40-85 years. GLI-based spirometric categories included normal-for-age and the impairments of restrictive-pattern and three-level severity of airflow-obstruction (mild, moderate, severe). GLI-based diffusion included diffusing capacity of the lung for carbon monoxide (D_LCO) and measured components of alveolar volume (V_A) and transfer coefficient (K_CO): D_LCO = [V_A</

SUBMITTER: Vaz Fragoso CA 

PROVIDER: S-EPMC7453093 | biostudies-literature | 2020 Aug - Sep

REPOSITORIES: biostudies-literature