Respiratory physiology of COVID-19-induced respiratory failure compared to ARDS of other etiologies.

ABSTRACT:

Background

Whether respiratory physiology of COVID-19-induced respiratory failure is different from acute respiratory distress syndrome (ARDS) of other etiologies is unclear. We conducted a single-center study to describe respiratory mechanics and response to positive end-expiratory pressure (PEEP) in COVID-19 ARDS and to compare COVID-19 patients to matched-control subjects with ARDS from other causes.

Methods

Thirty consecutive COVID-19 patients admitted to an intensive care unit in Rome, Italy, and fulfilling moderate-to-severe ARDS criteria were enrolled within 24 h from endotracheal intubation. Gas exchange, respiratory mechanics, and ventilatory ratio were measured at PEEP of 15 and 5 cmH₂O. A single-breath derecruitment maneuver was performed to assess recr

SUBMITTER: Grieco DL 

PROVIDER: S-EPMC7453378 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature