3-Methylxanthine production through biodegradation of theobromine by Aspergillus sydowii PT-2.

ABSTRACT:

Background

Methylxanthines, including caffeine, theobromine and theophylline, are natural and synthetic compounds in tea, which could be metabolized by certain kinds of bacteria and fungi. Previous studies confirmed that several microbial isolates from Pu-erh tea could degrade and convert caffeine and theophylline. We speculated that these candidate isolates also could degrade and convert theobromine through N-demethylation and oxidation. In this study, seven tea-derived fungal strains were inoculated into various theobromine agar medias and theobromine liquid mediums to assess their capacity in theobromine utilization. Related metabolites with theobromine degradation were detected by using HPLC in the liquid culture to investigate their potential application in the production of 3

SUBMITTER: Zhou B 

PROVIDER: S-EPMC7453516 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature