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Overcoming Adaptive Resistance to KRAS Inhibitors Through Vertical Pathway Targeting.

ABSTRACT: KRAS G12C inhibitors have shown promise in KRAS G12C-mutant lung cancer but intrinsic and acquired resistance are common. Cotreatment with inhibitors of the protein phosphatase SHP2 can abrogate the adaptive response of cancer cells to KRAS inhibitors resulting in greater suppression of MAPK signaling and enhanced tumor growth inhibition.See related article by Ryan et al., p. 1633.

SUBMITTER: Yaeger R

PROVIDER: S-EPMC7453631 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Overcoming Adaptive Resistance to KRAS Inhibitors Through Vertical Pathway Targeting.

Yaeger Rona R Solit David B DB

Clinical cancer research : an official journal of the American Association for Cancer Research 20200130 7

KRAS G12C inhibitors have shown promise in KRAS G12C-mutant lung cancer but intrinsic and acquired resistance are common. Cotreatment with inhibitors of the protein phosphatase SHP2 can abrogate the adaptive response of cancer cells to KRAS inhibitors resulting in greater suppression of MAPK signaling and enhanced tumor growth inhibition.See related article by Ryan et al., p. 1633. ...[more]

PMID: 32001483

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