Regulation of the mitochondrial permeability transition pore and its effects on aging.

ABSTRACT: Aging is an evolutionarily conserved process and is tightly connected to mitochondria. To uncover the aging molecular mechanisms related to mitochondria, different organisms have been extensively used as model systems. Among these, the budding yeast Saccharomyces cerevisiae has been reported multiple times as a model of choice when studying cellular aging. In particular, yeast provides a quick and trustworthy system to identify shared aging genes and pathway patterns. In this viewpoint on aging and mitochondria, I will focus on the mitochondrial permeability transition pore (mPTP), which has been reported and proposed as a main player in cellular aging. I will make several parallelisms with yeast to highlight how this unicellular organism can be used as a guidance system to understa

SUBMITTER: Pellegrino-Coppola D 

PROVIDER: S-EPMC7453641 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature