Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury.

ABSTRACT: There have been few studies investigating the potential effects of indoor sources of particulate matter on human health. In this study, the effect of different concentrations of fine particulate matter (PM2.5) collected from a printing room on lung health was examined using cultured cells and a mouse model. Further, the mechanism of lung injury was examined. The results indicated that PM2.5 significantly enhanced malondialdehyde activity (P<0.05), decreased superoxide dismutase activity (P<0.05), upregulated the expression of pro‑inflammatory factors including interleukin (IL)‑1β, tumor necrosis factor‑, IL‑6 and downregulated the expression of the inflammatory factor IL‑2 (P<0.05). Western blot analysis indicated that PM2.5 significantly enhanced expression of phosphorylated (p)‑ERK relat

SUBMITTER: Zou C 

PROVIDER: S-EPMC7453667 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature