Propagation of uncertainty in the mechanical and biological response of growing tissues using multi-fidelity Gaussian process regression.

ABSTRACT: A key feature of living tissues is their capacity to remodel and grow in response to environmental cues. Within continuum mechanics, this process can be captured with the multiplicative split of the deformation gradient into growth and elastic contributions. The mechanical and biological response during tissue adaptation is characterized by inherent variability. Accounting for this uncertainty is critical to better understand tissue mechanobiology, and, moreover, it is of practical importance if we aim to develop predictive models for clinical use. However, the current gold standard in computational models of growth and remodeling remains the use of deterministic finite element (FE) simulations. Here we focus on tissue expansion, a popular technique in which skin is stretched by a balloon-

SUBMITTER: Lee T 

PROVIDER: S-EPMC7453758 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature