Microbiota Supplementation with <i>Bifidobacterium</i> and <i>Lactobacillus</i> Modifies the Preterm Infant Gut Microbiota and Metabolome: An Observational Study.

ABSTRACT: Supplementation with members of the early-life microbiota as "probiotics" is increasingly used in attempts to beneficially manipulate the preterm infant gut microbiota. We performed a large observational longitudinal study comprising two preterm groups: 101 infants orally supplemented with Bifidobacterium and Lactobacillus (Bif/Lacto) and 133 infants non-supplemented (control) matched by age, sex, and delivery method. 16S rRNA gene profiling on fecal samples (n = 592) showed a predominance of Bifidobacterium and a lower abundance of pathobionts in the Bif/Lacto group. Metabolomic analysis showed higher fecal acetate and lactate and a lower fecal pH in the Bif/Lacto group compared to the control group. Fecal acetate positively correlated with relative abundance of Bi

SUBMITTER: Alcon-Giner C 

PROVIDER: S-EPMC7453906 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature