Individual cell-only bioink and photocurable supporting medium for 3D printing and generation of engineered tissues with complex geometries.

ABSTRACT: Scaffold-free engineering of three-dimensional (3D) tissue has focused on building sophisticated structures to achieve functional constructs. Although the development of advanced manufacturing techniques such as 3D printing has brought remarkable capabilities to the field of tissue engineering, technology to create and culture individual cell only-based high-resolution tissues, without an intervening biomaterial scaffold to maintain construct shape and architecture, has been unachievable to date. In this report, we introduce a cell printing platform which addresses the aforementioned challenge and permits 3D printing and long-term culture of a living cell-only bioink lacking a biomaterial carrier for functional tissue formation. A biodegradable and photocrosslinkable microgel supporting ba

SUBMITTER: Jeon O 

PROVIDER: S-EPMC7453938 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature