Meta-analysis of safety and efficacy of oral anticoagulants in patients requiring catheter ablation for atrial fibrillation.

ABSTRACT:

Background

The ideal oral anticoagulant agent during catheter ablation (CA) for atrial fibrillation (AF) remained unclear.

Hypothesis

Novel oral anticoagulants (NOACs) are safer and effective compared to uninterrupted vitamin K antagonists (U-VKA) among patients requiring CA for AF.

Methods

Four randomized controlled trials (RCTs) and 9 observational studies (OS) were selected using PubMed/Medline, EMBASE and the CENTRAL data bases (Inception-December-2017). Estimates were reported as random effects risk ratio (RR) with 95% confidence interval (CI). The primary safety outcome was major bleeding and main efficacy endpoint was thromboembolism.

Results

In RCTs restricted analysis, NOACs significantly reduced the relative risk of major bleeding by 72% compared to U

SUBMITTER: Rahman H 

PROVIDER: S-EPMC7453962 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature