Linear and nonlinear mechanical responses can be quite different in models for biological tissues.

ABSTRACT: The fluidity of biological tissues - whether cells can change neighbors and rearrange - is important for their function. In traditional materials, researchers have used linear response functions, such as the shear modulus, to accurately predict whether a material will behave as a fluid. Similarly, in disordered 2D vertex models for confluent biological tissues, the shear modulus becomes zero precisely when the cells can change neighbors and the tissue fluidizes, at a critical value of control parameter s₀* = 3.81. However, the ordered ground states of 2D vertex models become linearly unstable at a lower value of control parameter (3.72), suggesting that there may be a decoupling between linear and nonlinear response. We demonstrate that the linear response does not correctly pre

SUBMITTER: Sahu P 

PROVIDER: S-EPMC7453973 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature