Individualising care in severe bronchopulmonary dysplasia: a series of N-of-1 trials comparing transpyloric and gastric feeding.

ABSTRACT:

Objective

Compare rates of hypoxaemia during transpyloric and gastric feedings in very preterm infants with severe bronchopulmonary dysplasia.

Design

N-of-1 multiple crossover trials with individual patient and pooled data analyses.

Setting

Level IV intensive care nursery.

Patients

Infants receiving positive airway pressure between 36 and 55 weeks postmenstrual age were enrolled between December 2014-July 2016.

Intervention

N-of-1 trial consisting of two blocks, each with a 4-day gastric and 4-day transpyloric feeding period assigned in random order.

Main outcome measures

The primary outcome was the frequency of daily intermittent hypoxaemic events (SpO₂ ≤80% lasting 10-180 s). Secondary outcomes included the daily proportion of time wi

SUBMITTER: Jensen EA 

PROVIDER: S-EPMC7453998 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature