Noninvasive three-state sleep-wake staging in mice using electric field sensors.

ABSTRACT:

Study objective

Validate a novel method for sleep-wake staging in mice using noninvasive electric field (EF) sensors.

Methods

Mice were implanted with electroencephalogram (EEG) and electromyogram (EMG) electrodes and housed individually. Noninvasive EF sensors were attached to the exterior of each chamber to record respiration and other movement simultaneously with EEG, EMG, and video. A sleep-wake scoring method based on EF sensor data was developed with reference to EEG/EMG and then validated by three expert scorers. Additionally, novice scorers without sleep-wake scoring experience were self-trained to score sleep using only the EF sensor data, and results were compared to those from expert scorers. Lastly, ability to capture three-state sleep-wake staging with EF sensor

SUBMITTER: Kloefkorn H 

PROVIDER: S-EPMC7454007 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature