The Association of Multiparity with Lung Function and Chronic Obstructive Pulmonary Disease-Related Phenotypes.

ABSTRACT:

Background

Apparent increased female susceptibility to chronic obstructive pulmonary disease (COPD) suggests sex hormones modulate disease pathogenesis. Little is known about associations between multiparity and lung function in smokers.

Research question

We hypothesized that multiparity is associated with lung function and measures of emphysema and airway disease.

Study design and methods

Utilizing female participants from the 5-year follow up of the COPD Genetic Epidemiology (COPDGene^®) study we performed multivariable linear regressions to assess the effect of multiparity and number of pregnancies on forced expiratory volume in 1 second (FEV₁) percentage of predicted (% predicted), FEV₁/forced vital capacity (FVC), percent emphysema

SUBMITTER: Moll M 

PROVIDER: S-EPMC7454017 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature