Ontology highlight
ABSTRACT:
SUBMITTER: Zhao SG
PROVIDER: S-EPMC7454228 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Zhao Shuang G SG Chen William S WS Li Haolong H Foye Adam A Zhang Meng M Sjöström Martin M Aggarwal Rahul R Playdle Denise D Liao Arnold A Alumkal Joshi J JJ Das Rajdeep R Chou Jonathan J Hua Junjie T JT Barnard Travis J TJ Bailey Adina M AM Chow Eric D ED Perry Marc D MD Dang Ha X HX Yang Rendong R Moussavi-Baygi Ruhollah R Zhang Li L Alshalalfa Mohammed M Laura Chang S S Houlahan Kathleen E KE Shiah Yu-Jia YJ Beer Tomasz M TM Thomas George G Chi Kim N KN Gleave Martin M Zoubeidi Amina A Reiter Robert E RE Rettig Matthew B MB Witte Owen O Yvonne Kim M M Fong Lawrence L Spratt Daniel E DE Morgan Todd M TM Bose Rohit R Huang Franklin W FW Li Hui H Chesner Lisa L Shenoy Tanushree T Goodarzi Hani H Asangani Irfan A IA Sandhu Shahneen S Lang Joshua M JM Mahajan Nupam P NP Lara Primo N PN Evans Christopher P CP Febbo Phillip P Batzoglou Serafim S Knudsen Karen E KE He Housheng H HH Huang Jiaoti J Zwart Wilbert W Costello Joseph F JF Luo Jianhua J Tomlins Scott A SA Wyatt Alexander W AW Dehm Scott M SM Ashworth Alan A Gilbert Luke A LA Boutros Paul C PC Farh Kyle K Chinnaiyan Arul M AM Maher Christopher A CA Small Eric J EJ Quigley David A DA Feng Felix Y FY
Nature genetics 20200713 8
Although DNA methylation is a key regulator of gene expression, the comprehensive methylation landscape of metastatic cancer has never been defined. Through whole-genome bisulfite sequencing paired with deep whole-genome and transcriptome sequencing of 100 castration-resistant prostate metastases, we discovered alterations affecting driver genes that were detectable only with integrated whole-genome approaches. Notably, we observed that 22% of tumors exhibited a novel epigenomic subtype associat ...[more]