SARS-CoV-2 Infection-Associated Hemophagocytic Lymphohistiocytosis.

ABSTRACT:

Objectives

A subset of coronavirus disease 2019 (COVID-19) patients exhibit clinical features of cytokine storm. However, clinicopathologic features diagnostic of hemophagocytic lymphohistiocytosis (HLH) have not been reported. We studied the reticuloendothelial organs of 4 consecutive patients who died of COVID-19 and correlated with clinical and laboratory parameters to detect HLH.

Methods

Autopsies were performed on 4 patients who died of COVID-19. Routine H&E staining and immunohistochemical staining for CD163 were performed to detect hemophagocytosis. Clinical and laboratory results from premortem blood samples were used to calculate H-scores.

Results

All 4 cases demonstrated diffuse alveolar damage within the lungs. Three of the 4 cases had histologic evidence o

SUBMITTER: Prilutskiy A 

PROVIDER: S-EPMC7454285 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature