Successful treatment of acute heart failure in COVID-19-induced cytokine storm with tocilizumab: a case report.

ABSTRACT:

Background

SARS-CoV-2 is known to induce a cytokine storm, a hyperinflammatory state driven by up-regulation of interleukin 6 (IL-6) and immunomodulatory chemokines that may result in acute heart failure.

Case summary

A 65-year-old woman with confirmed SARS-CoV-2 developed shock with multiorgan system failure, including acute biventricular heart failure, 2 weeks after the initial onset of fever, cough, and shortness of breath. The patient experienced myocardial recovery within 48 h after administration of tocilizumab, a humanized monoclonal anti-IL-6 receptor antibody, and multiple supportive vasoactive medications.

Discussion

The differential diagnosis of acute heart failure in critically ill patients with COVID-19 infection is broad, including sepsis-induced cardiom

SUBMITTER: Chitturi KR 

PROVIDER: S-EPMC7454490 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature