Direct Observation of Repeated Infections With Endemic Coronaviruses.

ABSTRACT:

Background

Although the mechanisms of adaptive immunity to pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are still unknown, the immune response to the widespread endemic coronaviruses HKU1, 229E, NL63, and OC43 provide a useful reference for understanding repeat infection risk.

Methods

Here we used data from proactive sampling carried out in New York City from fall 2016 to spring 2018. We combined weekly nasal swab collection with self-reports of respiratory symptoms from 191 participants to investigate the profile of recurring infections with endemic coronaviruses.

Results

During the study, 12 individuals tested positive multiple times for the same coronavirus. We found no significant difference between the probability of testing positive at l

SUBMITTER: Galanti M 

PROVIDER: S-EPMC7454749 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature