AXIN2 expression predicts prostate cancer recurrence and regulates invasion and tumor growth.

ABSTRACT:

Background

Treatment of prostate cancer (PCa) may be improved by identifying biological mechanisms of tumor growth that directly impact clinical disease progression. We investigated whether genes associated with a highly tumorigenic, drug resistant, progenitor phenotype impact PCa biology and recurrence.

Methods

Radical prostatectomy (RP) specimens (±disease recurrence, N = 276) were analyzed by qRT-PCR to quantify expression of genes associated with self-renewal, drug resistance, and tumorigenicity in prior studies. Associations between gene expression and PCa recurrence were confirmed by bootstrap internal validation and by external validation in independent cohorts (total N = 675) and in silico. siRNA knockdown and lentiviral overexpression were used to determine the effe

SUBMITTER: Hu BR 

PROVIDER: S-EPMC7455032 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature