Fecal viral shedding in COVID-19 patients: Clinical significance, viral load dynamics and survival analysis.

ABSTRACT:

Background

To investigate the clinical significance, viral shedding duration and viral load dynamics of positive fecal SARS-CoV-2 signals in COVID-19.

Methods

COVID-19 patients were included. SARS-CoV-2 RNA was tested in stool and respiratory specimens until two sequential negative results were obtained. Clinical, laboratory and imaging data were recorded.

Results

Of the 69 COVID-19 patients, 20 (28.99 %) had positive fecal viral tests who were younger, had lower C-reactive protein (CRP) and fibrinogen (FIB) levels on admission (all P < 0.05), and showed more improvement and less progression on chest CT during recovery. The median duration of positive viral signals was significantly longer in stool samples than in respiratory samples (P < 0.05). In spite of the negati

SUBMITTER: Wang X 

PROVIDER: S-EPMC7455175 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature