The effect of oral and nasal breathing on the deposition of inhaled particles in upper and tracheobronchial airways.

ABSTRACT: The inhalation route has a substantial influence on the fate of inhaled particles. An outbreak of infectious diseases such as COVID-19, influenza or tuberculosis depends on the site of deposition of the inhaled pathogens. But the knowledge of respiratory deposition is important also for occupational safety or targeted delivery of inhaled pharmaceuticals. Simulations utilizing computational fluid dynamics are becoming available to a wide spectrum of users and they can undoubtedly bring detailed predictions of regional deposition of particles. However, if those simulations are to be trusted, they must be validated by experimental data. This article presents simulations and experiments performed on a geometry of airways which is available to other users and thus those results can be used for

SUBMITTER: Lizal F 

PROVIDER: S-EPMC7455204 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature