Neural signatures of α2-Adrenergic agonist-induced unconsciousness and awakening by antagonist.

ABSTRACT: How the brain dynamics change during anesthetic-induced altered states of consciousness is not completely understood. The α2-adrenergic agonists are unique. They generate unconsciousness selectively through α2-adrenergic receptors and related circuits. We studied intracortical neuronal dynamics during transitions of loss of consciousness (LOC) with the α2-adrenergic agonist dexmedetomidine and return of consciousness (ROC) in a functionally interconnecting somatosensory and ventral premotor network in non-human primates. LOC, ROC and full task performance recovery were all associated with distinct neural changes. The early recovery demonstrated characteristic intermediate dynamics distinguished by sustained high spindle activities. Awakening by the α2-adrenergic antagonist completely elimi

SUBMITTER: Ballesteros JJ 

PROVIDER: S-EPMC7455241 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature