Longitudinal structural and metabolic changes in frontotemporal dementia.

ABSTRACT:

Objective

To compare the sensitivity of structural MRI and ¹⁸F-fludeoxyglucose PET (¹⁸FDG-PET) to detect longitudinal changes in frontotemporal dementia (FTD).

Methods

Thirty patients with behavioral variant FTD (bvFTD), 7 with nonfluent/agrammatic variant primary progressive aphasia (nfvPPA), 16 with semantic variant primary progressive aphasia (svPPA), and 43 cognitively normal controls underwent 2-4 MRI and ¹⁸FDG-PET scans (total scans/visit = 270) as part of the Frontotemporal Lobar Degeneration Neuroimaging Initiative study. Linear mixed-effects models were carried out voxel-wise and in regions of interest to identify areas showing decreased volume or metabolism over time in patients as compared to controls.

Results

At baseline, p

SUBMITTER: Bejanin A 

PROVIDER: S-EPMC7455324 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature