Sex-driven modifiers of Alzheimer risk: A multimodality brain imaging study.

ABSTRACT:

Objective

To investigate sex differences in late-onset Alzheimer disease (AD) risks by means of multimodality brain biomarkers (β-amyloid load via ¹¹C-Pittsburgh compound B [PiB] PET, neurodegeneration via ¹⁸F-fluorodeoxyglucose [FDG] PET and structural MRI).

Methods

We examined 121 cognitively normal participants (85 women and 36 men) 40 to 65 years of age with clinical, laboratory, neuropsychological, lifestyle, MRI, FDG- and PiB-PET examinations. Several clinical (e.g., age, education, APOE status, family history), medical (e.g., depression, diabetes mellitus, hyperlipidemia), hormonal (e.g., thyroid disease, menopause), and lifestyle AD risk factors (e.g., smoking, diet, exercise, intellectual activity) were assessed. Statistical parametric m

SUBMITTER: Rahman A 

PROVIDER: S-EPMC7455325 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature