Multimodal longitudinal study of structural brain involvement in amyotrophic lateral sclerosis.

ABSTRACT:

Objective

To understand the progressive nature of amyotrophic lateral sclerosis (ALS) by investigating differential brain patterns of gray and white matter involvement in clinically or genetically defined subgroups of patients using cross-sectional, longitudinal, and multimodal MRI.

Methods

We assessed cortical thickness, subcortical volumes, and white matter connectivity from T1-weighted and diffusion-weighted MRI in 292 patients with ALS (follow-up: n = 150) and 156 controls (follow-up: n = 72). Linear mixed-effects models were used to assess changes in structural brain measurements over time in patients compared to controls.

Results

Patients with a C9orf72 mutation (n = 24) showed widespread gray and white matter involvement at baseline, and extensive loss o

SUBMITTER: van der Burgh HK 

PROVIDER: S-EPMC7455328 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature