Plasma neurofilament light levels are associated with risk of disability in multiple sclerosis.

ABSTRACT:

Objective

To investigate the association between plasma neurofilament light chain (pNfL) levels and the risk of developing sustained disability worsening.

Methods

Concentrations of pNfL were determined in 4,385 persons with multiple sclerosis (MS) and 1,026 randomly selected population-based sex- and age-matched controls using the highly sensitive Single Molecule Array (SimoaTM) NF-Light Advantage Kit. We assessed the impact of age-stratified pNfL levels above the 80th, 95th, and 99th percentiles among controls on the risk of Expanded Disability Status Scale (EDSS) worsening within the following year and reaching sustained EDSS scores of 3.0, 4.0, and 6.0 and conversion to secondary progressive multiple sclerosis (SPMS).

Results

The median (interquartile range [IQR])

SUBMITTER: Manouchehrinia A 

PROVIDER: S-EPMC7455371 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature