Genomic comparison of Clostridium chauvoei isolates from classical and visceral clinical manifestation.

ABSTRACT: Clostridium chauvoei is the etiological agent of blackleg, an infectious disease affecting cattle and small ruminants worldwide. This disease can manifest as classical blackleg, a condition in which skeletal muscles are affected and visceral blackleg, which affects the heart, sublingual muscles, and the diaphragm. The pathogenesis of the visceral form of the disease is poorly understood. The objective of this study is to determine and analyze complete genomic sequences of six C. chauvoei strains, five isolates from skeletal muscle and one isolate from a visceral case of blackleg in Brazil, to provide insights into the differences in pathogenic profiles of strains causing the different forms of disease. The full genomes of the six C. chauvoei strains were sequenced and comparative analyses

SUBMITTER: Ziech RE 

PROVIDER: S-EPMC7455654 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature