In silico analysis and homology modeling of strictosidine synthase involved in alkaloid biosynthesis in catharanthus roseus.

ABSTRACT:

Background

In this study, strictosidine synthase (STR) from Catharanthus roseus that plays an important role in alkaloid biosynthesis was selected. The purpose of this work was to perform in silico analysis and to predict the three-dimensional structure of this protein that is not available.

Results

Physicochemical characterization was performed by Expasy's Protparam server. The computed theoretical isoelectric point (pI) found to be less than 7 indicates the acidic nature of this protein. The aliphatic index 73.04 indicates the thermal stability of the protein. Grand average hydropathy (GRAVY) was predicted to be - 285; this lower value of GRAVY shows the possibility of better interaction of this protein with water. Functional analysis of these proteins was performed by SOS

SUBMITTER: Sahay A 

PROVIDER: S-EPMC7455670 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature