Donor myeloid derived suppressor cells (MDSCs) prolong allogeneic cardiac graft survival through programming of recipient myeloid cells in vivo.

ABSTRACT: Solid organ transplantation is a lifesaving therapy for patients with end-organ disease. Current immunosuppression protocols are not designed to target antigen-specific alloimmunity and are uncapable of preventing chronic allograft injury. As myeloid-derived suppressor cells (MDSCs) are potent immunoregulatory cells, we tested whether donor-derived MDSCs can protect heart transplant allografts in an antigen-specific manner. C57BL/6 (H2K^b, I-A^b) recipients pre-treated with BALB/c MDSCs were transplanted with either donor-type (BALB/c, H2K^d, I-A^d) or third-party (C3H, H2K^k, I-A^k) cardiac grafts. Spleens and allografts from C57BL/6 recipients were harvested for immune phenotyping, transcriptomic profiling and functional assays.

SUBMITTER: Cai S 

PROVIDER: S-EPMC7455707 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature