Ontology highlight
ABSTRACT:
SUBMITTER: Manoranjan B
PROVIDER: S-EPMC7455709 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Nature communications 20200828 1
Medulloblastoma (MB) is defined by four molecular subgroups (Wnt, Shh, Group 3, Group 4) with Wnt MB having the most favorable prognosis. Since prior reports have illustrated the antitumorigenic role of Wnt activation in Shh MB, we aimed to assess the effects of activated canonical Wnt signaling in Group 3 and 4 MBs. By using primary patient-derived MB brain tumor-initiating cell (BTIC) lines, we characterize differences in the tumor-initiating capacity of Wnt, Group 3, and Group 4 MB. With sing ...[more]