Non-invasive screening for subclinical liver graft injury in adults via donor-specific anti-HLA antibodies.

ABSTRACT: The majority of liver grafts exhibit abnormal histological findings late after transplantation, even when liver enzymes are normal. Such subclinical graft injuries were associated with rejection and fibrosis progression in recent studies. The identification of non-invasive biomarkers for subclinical graft injury might help to individualize immunosuppression. Therefore, graft injury was assessed in 133 liver biopsies with normal/near normal liver enzymes from a prospective liver biopsy program. Cytokeratin-18 cell death marker (M65) and donor specific anti-HLA antibodies (DSA) were measured as non-invasive markers in paired plasma samples in addition to routine parameters. M65 was associated with subclinical graft injury but this association was too weak for reasonable clinical application.

SUBMITTER: Hofer A 

PROVIDER: S-EPMC7455737 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature