Association between the Lymphotoxin-α A252g Gene Polymorphism and the Risk of Sepsis and Mortality: A Meta-Analysis.

ABSTRACT:

Background

The association between the lymphotoxin-α (LTA) A252G polymorphism and sepsis risk has been extensively studied, but the results have been controversial. This study is aimed at investigating the overall association between the LTA A252G polymorphism and the risk of sepsis/septic shock and sepsis-related mortality.

Methods

We searched the PubMed and EMBASE databases to identify studies that investigated the association between the LTA A252G polymorphism and risks of sepsis, septic shock, and mortality. The relevant data were extracted, and statistical analyses were performed using the Revman 5.0 and STATA 12 software.

Results

A total of 32 publications were included in the meta-analysis. The results demonstrated that the LTA

SUBMITTER: Guo S 

PROVIDER: S-EPMC7455838 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature