Application of network pharmacology and molecular docking to elucidate the potential mechanism of Eucommia ulmoides-Radix Achyranthis Bidentatae against osteoarthritis.

ABSTRACT:

Background

Osteoarthritis is a disabling disease, which seriously affects the quality of life of patients. Increasing evidence has indicated that Chinese herbal medicine including Eucommia ulmoides (EU) and Radix Achyranthis Bidentatae (RAB) have potential in the treatment of osteoarthritis, and this is associated with their multi-target and multi-link action characteristics. Although their potential anti-arthritic activity has been reported, the exact mechanism of EU-RAB action in osteoarthritis remains unexplored. Therefore, this study explores the mechanism of EU-RAB against osteoarthritis using network pharmacology and molecular docking technology.

Methods

Public databases including TCMSP、BATMAN-TCM、OMIM and Genecards were used to predict the bioactive ingr

SUBMITTER: Jian GH 

PROVIDER: S-EPMC7456016 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature