Prognostic significance of the albumin-to-globulin ratio for upper tract urothelial carcinoma.

ABSTRACT:

Background

Although the albumin-to-globulin ratio (AGR) is a promising biomarker for various malignancies, few studies have investigated its prognostic significance for upper tract urothelial carcinoma (UTUC).

Methods

This retrospective study conformed to the REporting recommendations for tumour MARKer prognostic studies (REMARK) guideline. We reviewed 179 patients with UTUC who underwent radical nephroureterectomy at our institution between 2008 and 2018. Associations of preoperative clinicopathological factors, including the AGR, with cancer-specific survival (CSS) and overall survival (OS) were assessed. The Cox proportional hazards model was used for univariate and multivariable analyses. AGR was dichotomized as < 1.25 and ≥ 1.25, according to the most discriminatory cut

SUBMITTER: Omura S 

PROVIDER: S-EPMC7456038 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature