Efficacy assessment of mesenchymal stem cell transplantation for burn wounds in animals: a systematic review.

ABSTRACT:

Background

Clinically, severe burns remain one of the most challenging issues, but an ideal treatment is yet absent. Our purpose is to compare the efficacy of stem cell therapy in a preclinical model of burn wound healing.

Methods

Research reports on mesenchymal stem cells (MSCs) for burn wound healing were retrieved from 5 databases: PubMed, Embase, MEDLINE, Web of Science, and the Cochrane Library. The primary outcomes reported in this article include the un-healing rate of the wound area, the closure rate, and the wound area. Secondary outcomes included CD-31, vascular density, interleukin (IL)-10, thickness of eschar tissue, vascular endothelial growth factor (VEGF), and white blood cell count. Finally, a subgroup analysis was conducted to explore heterogeneity that pote

SUBMITTER: Yi H 

PROVIDER: S-EPMC7456061 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature