Estimating the genome-wide contribution of selection to temporal allele frequency change.

ABSTRACT: Rapid phenotypic adaptation is often observed in natural populations and selection experiments. However, detecting the genome-wide impact of this selection is difficult since adaptation often proceeds from standing variation and selection on polygenic traits, both of which may leave faint genomic signals indistinguishable from a noisy background of genetic drift. One promising signal comes from the genome-wide covariance between allele frequency changes observable from temporal genomic data (e.g., evolve-and-resequence studies). These temporal covariances reflect how heritable fitness variation in the population leads changes in allele frequencies at one time point to be predictive of the changes at later time points, as alleles are indirectly selected due to remaining associations with se

SUBMITTER: Buffalo V 

PROVIDER: S-EPMC7456072 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature