Activator protein-1 transactivation of the major immediate early locus is a determinant of cytomegalovirus reactivation from latency.

ABSTRACT: Human cytomegalovirus (HCMV) is a ubiquitous pathogen that latently infects hematopoietic cells and has the ability to reactivate when triggered by immunological stress. This reactivation causes significant morbidity and mortality in immune-deficient patients, who are unable to control viral dissemination. While a competent immune system helps prevent clinically detectable viremia, a portrait of the factors that induce reactivation following the proper cues remains incomplete. Our understanding of the complex molecular mechanisms underlying latency and reactivation continues to evolve. We previously showed the HCMV-encoded G protein-coupled receptor US28 is expressed during latency and facilitates latent infection by attenuating the activator protein-1 (AP-1) transcription factor su

SUBMITTER: Krishna BA 

PROVIDER: S-EPMC7456108 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature