Chronic G_q signaling in AgRP neurons does not cause obesity.

ABSTRACT: Maintaining energy homeostasis requires coordinating physiology and behavior both on an acute timescale to adapt to rapid fluctuations in caloric intake and on a chronic timescale to regulate body composition. Hypothalamic agouti-related peptide (AgRP)-expressing neurons are acutely activated by caloric need, and this acute activation promotes increased food intake and decreased energy expenditure. On a longer timescale, AgRP neurons exhibit chronic hyperactivity under conditions of obesity and high dietary fat consumption, likely due to leptin resistance; however, the behavioral and metabolic effects of chronic AgRP neuronal hyperactivity remain unexplored. Here, we use chemogenetics to manipulate G_q signaling in AgRP neurons in mice to explore the hypothesis that chronic activ

SUBMITTER: Ewbank SN 

PROVIDER: S-EPMC7456117 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature