Evasion of MAIT cell recognition by the African <i>Salmonella</i> Typhimurium ST313 pathovar that causes invasive disease.

ABSTRACT: Mucosal-associated invariant T (MAIT) cells are innate T lymphocytes activated by bacteria that produce vitamin B2 metabolites. Mouse models of infection have demonstrated a role for MAIT cells in antimicrobial defense. However, proposed protective roles of MAIT cells in human infections remain unproven and clinical conditions associated with selective absence of MAIT cells have not been identified. We report that typhoidal and nontyphoidal Salmonella enterica strains activate MAIT cells. However, S. Typhimurium sequence type 313 (ST313) lineage 2 strains, which are responsible for the burden of multidrug-resistant nontyphoidal invasive disease in Africa, escape MAIT cell recognition through overexpression of ribB This bacterial gene encodes the 4-dihydroxy-2-butanone-

SUBMITTER: Preciado-Llanes L 

PROVIDER: S-EPMC7456131 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature