A 25-y longitudinal dolphin cohort supports that long-lived individuals in same environment exhibit variation in aging rates.

ABSTRACT: While it is believed that humans age at different rates, a lack of robust longitudinal human studies using consensus biomarkers meant to capture aging rates has hindered an understanding of the degree to which individuals vary in their rates of aging. Because bottlenose dolphins are long-lived mammals that develop comorbidities of aging similar to humans, we analyzed data from a well-controlled, 25-y longitudinal cohort of 144 US Navy dolphins housed in the same oceanic environment. Our analysis focused on 44 clinically relevant hematologic and clinical chemistry measures recorded during routine blood draws throughout the dolphins' lifetimes. Using stepwise regression and general linear models that accommodate correlations between measures obtained on individual dolphins, we demonstrate th

SUBMITTER: Venn-Watson S 

PROVIDER: S-EPMC7456138 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature